Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4861 |
| PDBID: | 7SCO |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/South Canterbury/35/2000(H1N1)), Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.37 |
| Reference: | 10.1016/j.immuni.2022.07.006 |
| Antibody | |
| Antibody: | 310-39G10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus South Canterbury/35/2000 H1N1 NC99 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7SCO_H|Chain C[auth E], G[auth H], K[auth J]|310-39G10 Fab, Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCKASGGTFSRYTISWVRQAPGQGLEWMGRISPIAGLENYAQKFQGRVTITADISTSTAYMELSSLRSDDTAVYYCAGSSGYYQPPPYWGQGTLVTVSS |
Light Chain: L
Mutation: NULL
| >7SCO_L|Chain D[auth F], H[auth K], L|310-39G10 Fab, Light Chain|Homo sapiens (9606) EIVLTQAPFSLSLSPGERATLSCRASQSVSSSSLAWYHQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFSLYYCQQYGSSPLTFGQGTRLEIK |
Antigen
Chain: A
Mutation: NULL
| >7SCO_A|Chain A, E[auth C], I[auth G]|Hemagglutinin HA1 chain|Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1) (363066) DTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCLLKGIAPLQLGNCSVAGWILGNPECELLISKESWSYIVETPNPENGTCYPGYFADYEELREQLSSVSSFERFEIFPKESSWPNHTVTGVSASCSHNGKSSFYRNLLWLTGKNGLYPNLSKSYVNNKEKEVLVLWGVHHPPNIGNQRALYHTENAYVSVVSSHYSRRFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGFGSGIITSNAPMDECDAKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSAKLRMVTGLRNIPS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: LYS530 ILE558 PRO560 ILE561 ALA562 GLY563 LEU564 GLU565 ILE581 SER582 THR583 SER584 A: HIS12 ASN14 HIS32 VAL34 LEU36 GLU38 ASP279 ASN290 SER291 SER292 LEU293 THR319 GLY320 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
