Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4858 |
| PDBID: | 7SCN |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/South Canterbury/35/2000(H1N1)), Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.02 |
| Reference: | 10.1016/j.immuni.2022.07.006 |
| Antibody | |
| Antibody: | 310-63E6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus South Canterbury/35/2000 H1N1 NC99 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7SCN_H|Chain C[auth E], G[auth H], K[auth J]|310-63E6 Fab, Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCTASGGTFSTYQFSWVRQAPGQGLEWMGRIVPIQGMDYAQKFRGRVTITADKWTSTVYMEVTSLRSEDTAVYYCATSRSMYFYYQLDVWGRGTTVTVSS |
Light Chain: L
Mutation: NULL
| >7SCN_L|Chain D[auth F], H[auth K], L|310-63E6 Fab, Light Chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATVSCRASQSVTSTFLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSEADFTLTINRLEPEDFAVYYCQQYATSPWTFGQGTKVEIK |
Antigen
Chain: A
Mutation: NULL
| >7SCN_A|Chain A, E[auth C], I[auth G]|Hemagglutinin HA1 chain|Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1) (363066) DTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCLLKGIAPLQLGNCSVAGWILGNPECELLISKESWSYIVETPNPENGTCYPGYFADYEELREQLSSVSSFERFEIFPKESSWPNHTVTGVSASCSHNGKSSFYRNLLWLTGKNGLYPNLSKSYVNNKEKEVLVLWGVHHPPNIGNQRALYHTENAYVSVVSSHYSRRFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGFGSGIITSNAPMDECDAKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSAKLRMVTGLRNIPS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER537 PRO560 ILE561 GLN562 ASP579 LYS580 TRP581 THR582 TYR609 PHE610 TYR611 A: HIS12 HIS32 SER33 VAL34 LEU36 LYS281 SER291 SER292 LEU293 PRO294 GLU305 CYS306 PRO307 THR319 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
