Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4855 |
| PDBID: | 7SCN |
| Chains: | HL_B |
| Organism: | Influenza A virus (A/South Canterbury/35/2000(H1N1)), Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.02 |
| Reference: | 10.1016/j.immuni.2022.07.006 |
| Antibody | |
| Antibody: | 310-63E6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus South Canterbury/35/2000 H1N1 NC99 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7SCN_H|Chain C[auth E], G[auth H], K[auth J]|310-63E6 Fab, Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCTASGGTFSTYQFSWVRQAPGQGLEWMGRIVPIQGMDYAQKFRGRVTITADKWTSTVYMEVTSLRSEDTAVYYCATSRSMYFYYQLDVWGRGTTVTVSS |
Light Chain: L
Mutation: NULL
| >7SCN_L|Chain D[auth F], H[auth K], L|310-63E6 Fab, Light Chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATVSCRASQSVTSTFLAWYQQRPGQAPRLLIYGASSRATGIPDRFSGSGSEADFTLTINRLEPEDFAVYYCQQYATSPWTFGQGTKVEIK |
Antigen
Chain: B
Mutation: NULL
| >7SCN_B|Chain B, F[auth D], J[auth I]|Hemagglutinin HA2 chain|Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1) (363066) RETRGLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNSVIEKMNTQFTAVGKEFNKLERRMENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVKNLYEKVKSQLKNNAKEIGNGCFEFYHKCNNECMESVKNGTYDYPKYSEESKLNREKIDGVKYIPEAPRDGQAYVRKDGEWVLLSTFLGSGLNDIFEAQKIEWHEGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR535 SER537 THR538 ILE561 LYS580 TRP581 ARG606 SER607 TYR609 PHE610 TYR611 TYR612 L: THR653 SER654 THR655 PHE656 TYR673 GLY674 SER677 B: VAL348 ASP349 GLY350 TRP351 TYR364 GLN368 THR371 GLN372 ILE375 ASN376 ILE378 THR379 VAL382 ASN383 ILE386 GLU387 THR391 GLN392 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
