Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4849 |
| PDBID: | 7SBD |
| Chains: | HL_C |
| Organism: | Mus musculus, Hevea brasiliensis |
| Method: | XRD |
| Resolution (Å): | 3.04 |
| Reference: | 10.1038/s42003-022-03718-w |
| Antibody | |
| Antibody: | 7SBD Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Profilin-2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7SBD_H|Chain A[auth H]|Fab/IgE Heavy chain|Mus musculus (10090) EVQLVESGGGLVQPKGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRTKTNNYVTYYADSVKDRFTISRDDSQSMLYLQMNNLKTEDTAMYYCVRHVGDYWGQGTSVTVSSASIRNPQLYPLKPCKGTASMTLGCLVKDYFPGPVTVTWYSDSLNMSTVNFPALGSELKVTTSQVTSWGKSAKNFTCHVTHPPSFNESRTILVR |
Light Chain: L
Mutation: NULL
| >7SBD_L|Chain B[auth L]|Fab/IgE Light chain|Mus musculus (10090) DIQMTQSPASLSASVGETVTITCRASGNIHNYLAWFQQKQGKSPQLLVYNAKTLADGVPSRFSGSGSGTQYSLKINSLQPEDFGSYYCQHFWSTPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: C
Mutation: NULL
| >7SBD_C|Chain C|Profilin-2|Hevea brasiliensis (3981) DDDKMSWQAYVDDHLMCEIEGNHLSAAAIIGQDGSVWAQSANFPQFKSEEITGIMSDFHEPGTLAPTGLYIGGTKYMVIQGEPGAVIRGKKGPGGVTVKKTNQALIIGIYDEPMTPGQCNMIVERLGDYLIDQGY |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR31 TYR32 ALA33 ARG50 ARG52 THR53 THR55 ASN56 HIS101 VAL102 L: ASN28 HIS30 ASN31 TYR32 TYR49 ASN50 LYS52 THR53 LEU54 PHE91 TRP92 TYR96 C: ASP-3 ASP-2 LYS0 MET1 TYR6 ASP9 HIS10 CYS13 GLU14 ILE15 GLU16 ALA81 LYS95 LYS96 THR97 ASN98 MET117 ILE118 ARG121 LEU122 ASP124 TYR125 ILE127 ASP128 GLN129 GLY130 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
