Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4846 |
| PDBID: | 7S7R |
| Chains: | B_A |
| Organism: | Plasmodium falciparum 3D7, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 1.77 |
| Reference: | 10.1093/femsmc/xtac005 |
| Antibody | |
| Antibody: | G7 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium falciparum merozoite surface protein P12 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >7S7R_B|Chain B|Nanobody G7|Vicugna pacos (30538) QVQLQESGGGLVQAGGSLRLSCAASGRTFSSYGMGWFRQAPGTEREFVAAISWSGDSTYYADSVKGRFTISIDKAKNTVYLQMNSLKPEDTAVYYCAADHALVVGGTYNYWGQGTQVTVSSHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >7S7R_A|Chain A|Merozoite surface protein P12|Plasmodium falciparum 3D7 (36329) GASNLTCDFNDVYKLEFHPNQQTSVTKLCNLTPNVLEKVTIKCGSDKLNYNLYPPTCFEEVYASRNMMHLKKIKEFVIGSSMFMRRSLTPNKINEVSFRIPPNMMPEKPIYCFCENKKTITINGSNGNPSSKKDIINRGIVEIIIPSLNEKVKGCDFTTSESTIFSKGYSINEISNKSSNNQQDIVCTVKAHANDLIGFKCPSNYSVEPHDCFVSAFNLSGKNENLENKLKLTNIIMDHYNNTFYSRLPSLISDNWKFFCVCSKDNEKKLVFTVEASISS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: THR28 SER31 TYR32 GLY33 PHE37 GLU44 GLU46 PHE47 ALA50 SER52 TRP53 ASP56 SER57 THR58 TYR59 ASP99 HIS100 LEU102 VAL103 VAL104 THR107 TYR108 TYR110 A: GLN207 ASP208 VAL210 THR212 LYS214 PHE241 ASN242 LEU243 SER244 GLY245 LYS246 ASN279 TRP280 LYS281 PHE283 VAL285 LYS293 VAL295 GLU299 ALA300 SER301 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
