Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4826 |
| PDBID: | 7S1B |
| Chains: | HL_A |
| Organism: | human gammaherpesvirus 4, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.03 |
| Reference: | 10.1016/j.immuni.2022.10.003 |
| Antibody | |
| Antibody: | 770F7 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Epstein-Barr virus glycoprotein H |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7S1B_H|Chain C[auth H]|770F7 Fab heavy chain|Homo sapiens (9606) QVQFQQWGAGLLKPSETLSLTCGVYGGSLSGYYWSWIRQTPGKGLEWIGEINHTGTTNYNPSLKSRVTMSVDTSKNQFSLKMSSLTAADTALYYCAREGAPRWALKRPSNWFDPWGQGTLVTVSSASTKGPSVFPLAPSSASTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK |
Light Chain: L
Mutation: NULL
| >7S1B_L|Chain D[auth L]|770F7 Fab light chain|Homo sapiens (9606) EIVLTQSPVSLSLSPGERATLSCRASQSLSSTYLAWYQQIPGQAPRLLIYGASSRAAGIPDRFSGGGSGTDFTLTISRLEPEDFAVYYCQQYGSSPRSFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7S1B_A|Chain A|Envelope glycoprotein H|Human gammaherpesvirus 4 (10376) ASLSEVKLHLDIEGHASHYTIPWTELMAKVPGLSPEALWREANVTEDLASMLNRYKLIYKTSGTLGIALAEPVDIPAVSEGSMQVDASKVHPGVISGLNSPACMLSAPLEKQLFYYIGTMLPNTRPHSYVFYQLRCHLSYVALSINGDKFQYTGAMTSKFLMGTYKRVTEKGDEHVLSLVFGKTKDLPDLRGPFSYPSLTSAQSGDYSLVIVTTFVHYANFHNYFVPNLKDMFSRAVTMTAASYARYVLQKLVLLEMKGGCREPELDTETLTTMFEVSVAFFKVGHAVGETGNGCVDLRWLAKSFFELTVLKDIIGICYGATVKGMQSYGLERLAAMLMATVKMEELGHLTTEKQEYALRLATVGYPKAGVYSGLIGGATSVLLSAYNRHPLFQPLHTVMRETLFIGSHVVLRELRLNVTTQGPNLALYQLLSTALCSALEIGEVLRGLALGTESGLFSPCYLSLRFDLTRDKLLSMAPQEATLDQAAVSNAVDGFLGRLSLEREDRDAWHLPAYKCVDRLDKVLMIIPLINVTFIISSDREVRGSALYEASTTYLSSSLFLSPVIMNKCSQGAVAGEPRQIPKIQNFTRTQKSCIFCGFALLSYDEKEGLETTTYITSQEVQNSILSSNYFDFDNLHVHYLLLTTNGTVMEIAGLY |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLN1 VAL2 GLY26 GLY27 SER28 SER30 GLY31 TYR32 THR54 ASN76 ARG97 GLY99 ALA100 PRO101 TRP103 ALA104 LEU105 LYS106 ARG107 PRO108 ASN110 TRP111 L: THR32 TYR33 ARG46 TYR50 SER54 ARG55 ALA57 GLY58 A: ILE334 LEU432 ARG433 LEU434 ASN435 VAL436 LEU519 GLU520 GLU522 ASP525 TRP527 TYR532 LYS533 VAL535 ASP536 ARG537 LEU538 ASP539 GLU559 ARG561 LYS586 CYS587 SER588 GLN589 GLY590 ALA591 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
