Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4825 |
| PDBID: | 7S1B |
| Chains: | XY_B |
| Organism: | human gammaherpesvirus 4, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.03 |
| Reference: | 10.1016/j.immuni.2022.10.003 |
| Antibody | |
| Antibody: | 769C2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Epstein-Barr virus glycoprotein L |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: X
Mutation: NULL
| >7S1B_X|Chain E[auth X]|769C2 Fab heavy chain|Homo sapiens (9606) EVQLVESGGGLVKPGGSLRLSCAASGFTFSTYAMDWVRQAPGKGLEWVSLISSRSSNIYYSDSVKGNFTISRDNAKNSLFLQMNSLRAEDTAVYYCAREAGGFHSHFDMWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK |
Light Chain: Y
Mutation: NULL
| >7S1B_Y|Chain F[auth Y]|769C2 Fab light chain|Homo sapiens (9606) QSVLTQPASVSGSLGQSVTISCTGTSSDVGGYDYVSWYQQHPGKNPKLMIFEVNNRPSGVSTRFSGSKSGNTASLTISGLQAEDEADYYCNSYSTTTTWVFGGGTSLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC |
Antigen
Chain: B
Mutation: NULL
| >7S1B_B|Chain B|Envelope glycoprotein L|Human gammaherpesvirus 4 (10376) WAYPCCHVTQLAAQHLLALENISDIYLVSNQTCDGFSLASLNSPKNGSNQLVISRCANGLNVVSFFISILKRSSSALTGHLRELLTTLETLYGSFSVEDLFGANLNRYAWHRGG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| X: THR31 SER53 ARG54 TYR59 PHE103 Y: TYR32 TYR34 TYR93 THR95 B: TYR49 LEU50 VAL51 GLN54 THR55 HIS103 GLU106 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
