Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4823 |
| PDBID: | 7S13 |
| Chains: | IM_C |
| Organism: | Rattus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.12 |
| Reference: | 10.1080/19420862.2021.1979800 |
| Antibody | |
| Antibody: | mCD96-B Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | CD96 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: I
Mutation: NULL
| >7S13_I|Chain A[auth H], C[auth I]|Fab heavy chain|Rattus (10114) QVQLKESGPGLVQPSQTLSLTCTVSGLSLTNNIVSWIRQPPGKGLEWMGVIWSNGGTDYNSAIKSRLSITRDTSKSQVFLKMNSLQTEDTAMYFCASRDYPGFAYWGQGTLVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGGHHHHHH |
Light Chain: M
Mutation: NULL
| >7S13_M|Chain B[auth L], D[auth M]|Fab light chain|Rattus (10114) YELIQPPSSSVTLGSTVSLTCVGDELPKRYAYWYQQKPDQSIVRVIYEDSKRPSGISDRFSGSSSGTTATLTIRDAQAEDEADYYCLSTYSDDKLPIFGGGTKLTVLGQPKSSPSVTLFPPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNKYMASSYLTLTARAWERHSSYSCQVTHEGHTVEKSLSRADCS |
Antigen
Chain: C
Mutation: NULL
| >7S13_C|Chain E[auth C], F[auth D]|T-cell surface protein tactile|Mus musculus (10090) GVWEELFNVGDDVYALPGSDINLTCQTKEKNFLVQMQWSKVTDKNDMIALYHPQYGLYCGQEHACESQVAATETEKGVTNWTLYLRNISSALGGKYECIFTLYPEGIKTTVYNLIVEPGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| I: VAL2 GLY26 LEU27 SER28 THR30 ASN31 ASN32 ILE33 TRP52 SER53 ASN54 ARG95 ASP96 TYR97 TYR102 M: TYR34 TYR49 GLU50 LYS53 ARG54 PRO55 SER56 C: TYR71 PRO73 GLN74 TYR75 GLY76 LEU77 TYR78 CYS79 GLN81 GLU82 HIS83 ALA84 GLU86 SER87 ALA90 ALA91 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
