Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4820 |
| PDBID: | 7S11 |
| Chains: | JN_E |
| Organism: | Mus musculus, Rattus |
| Method: | XRD |
| Resolution (Å): | 2.58 |
| Reference: | 10.1080/19420862.2021.1979800 |
| Antibody | |
| Antibody: | mCD96-A Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | CD96 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: J
Mutation: NULL
| >7S11_J|Chain B[auth H], E[auth I], H[auth J], K|Fab heavy chain|Rattus (10114) QVQLKESGPGLVQPSQTLSLTCTVSGLSLTTNSVSWIRQPPGKGLEWMGVIWSNGGTDYNSDIKSRLSISRDTSKSQVFLKMNSLQTEDTAMYFCARNFPYPGINFDWGQGVMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCGGHHHHHH |
Light Chain: N
Mutation: NULL
| >7S11_N|Chain C[auth L], F[auth M], I[auth N], L[auth O]|Fab light chain|Rattus (10114) QAVVTQESALTTLPGGTVTLTCHSSTGAVTTSNYANWIQEKADHSFTAILGGTSNRAPGTPARFSGSLLEGKAALTITGAQVEDEATYFCSLWYSGHLIFGGGTKLTVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >7S11_E|Chain A[auth C], D, G[auth E], J[auth F]|T-cell surface protein tactile|Mus musculus (10090) EELFNVGDDVYALPGSDINLTCQTKEKNFLVQMQWSKVTDKNDMIALYHPQYGLYCGQEHACESQVAATETEKGVTNWTLYLRNISSALGGKYECIFTLYPEGIKTTVYNLIVEPGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| J: VAL2 SER28 THR30 THR31 ASN32 SER33 TRP52 SER53 ASN54 ASP58 ARG94 ASN95 TYR98 PRO99 ASN100 N: SER30 TYR32 PRO56 TRP91 SER93 GLY94 E: VAL54 GLN55 MET67 LEU70 HIS72 PRO73 GLN74 TYR75 GLY76 LEU77 TYR78 CYS79 GLY80 GLN81 GLU86 TYR123 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
