Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4807 |
| PDBID: | 7S07 |
| Chains: | HL_B |
| Organism: | human gammaherpesvirus 4, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.29 |
| Reference: | 10.1016/j.immuni.2022.10.003 |
| Antibody | |
| Antibody: | 769B10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Epstein-Barr virus glycoprotein L |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7S07_H|Chain F[auth H]|769B10 Fab heavy chain|Homo sapiens (9606) EVQLVESGGGIVQPGGSLRVSCAASGFSLSDHYMDWVRQAPGRGLEWVGRSRNKENSFTTEFAASVRRRFTISRDDSNSLLHLQMNNLKSEDTAVYFCARVGYYDLWSGYSGNWYIDVWGRGTLVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGVLTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK |
Light Chain: L
Mutation: NULL
| >7S07_L|Chain G[auth L]|769B10 Fab light chain|Homo sapiens (9606) DIQMTQSPSSLSASLGDSVTITCRASQTMSNFLNWYQQKPGKAPKFLIYAASRLQSGVPSRFSGSGSGTQFTLTISNLQPEDFATYYCQQSFLFPYTFGGGTKVEVERTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >7S07_B|Chain B|Envelope glycoprotein L|Human gammaherpesvirus 4 (10376) PCCHVTQLAAQHLLALENISDIYLVSNQTCDGFSLASLNSPKNGSNQLVISRCANGLNVVSFFISILKRSSSALTGHLRELLTTLETLYGSFSVEDLF |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLU58 ALA61 ARG64 ARG65 L: PHE94 PRO95 B: ASP57 PHE59 GLU121 ASP122 LEU123 PHE124 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
