Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4806 |
| PDBID: | 7S07 |
| Chains: | HL_A |
| Organism: | human gammaherpesvirus 4, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.29 |
| Reference: | 10.1016/j.immuni.2022.10.003 |
| Antibody | |
| Antibody: | 769B10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Epstein-Barr virus glycoprotein H |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7S07_H|Chain F[auth H]|769B10 Fab heavy chain|Homo sapiens (9606) EVQLVESGGGIVQPGGSLRVSCAASGFSLSDHYMDWVRQAPGRGLEWVGRSRNKENSFTTEFAASVRRRFTISRDDSNSLLHLQMNNLKSEDTAVYFCARVGYYDLWSGYSGNWYIDVWGRGTLVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGVLTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK |
Light Chain: L
Mutation: NULL
| >7S07_L|Chain G[auth L]|769B10 Fab light chain|Homo sapiens (9606) DIQMTQSPSSLSASLGDSVTITCRASQTMSNFLNWYQQKPGKAPKFLIYAASRLQSGVPSRFSGSGSGTQFTLTISNLQPEDFATYYCQQSFLFPYTFGGGTKVEVERTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7S07_A|Chain A|Envelope glycoprotein H|Human gammaherpesvirus 4 (10376) ASLSEVKLHLDIEGHASHYTIPWTELMAKVPGLSPEALWREANVTEDLASMLNRYKLIYKTSGTLGIALAEPVDIPAVSEGSMQVDASKVHPGVISGLNSPACMLSAPLEKQLFYYIGTMLPNTRPHSYVFYQLRCHLSYVALSINGDKFQYTGAMTSKFLMGTYKRVTEKGDEHVLSLVFGKTKDLPDLRGPFSYPSLTSAQSGDYSLVIVTTFVHYANFHNYFVPNLKDMFSRAVTMTAASYARYVLQKLVLLEMKGGCREPELDTETLTTMFEVSVAFFKVGHAVGETGNGCVDLRWLAKSFFELTVLKDIIGICYGATVKGMQSYGLERLAAMLMATVKMEELGHLTTEKQEYALRLATVGYPKAGVYSGLIGGATSVLLSAYNRHPLFQPLHTVMRETLFIGSHVVLRELRLNVTTQGPNLALYQLLSTALCSALEIGEVLRGLALGTESGLFSPCYLSLRFDLTRDKLLSMAPQEATLDQAAVSNAVDGFLGRLSLEREDRDAWHLPAYKCVDRLDKVLMIIPLINVTFIISSDREVRGSALYEASTTYLSSSLFLSPVIMNKCSQGAVAGEPRQIPKIQNFTRTQKSCIFCGFALLSYDEKEGLETTTYITSQEVQNSILSSNYFDFDNLHVHYLLLTTNGTVMEIAGLY |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ARG50 GLU52 ASN53 TYR97 ASP99 L: ASP1 GLN27 THR28 SER30 ASN31 PHE32 SER67 PHE92 LEU93 PHE94 TYR96 A: LYS73 TYR76 LYS77 THR78 SER79 GLY80 THR81 LEU82 GLY83 SER218 PHE232 VAL233 TYR235 ALA236 ASN237 HIS239 ASN240 VAL243 PRO244 ASN245 LEU246 LYS247 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
