Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4803 |
| PDBID: | 7RXP |
| Chains: | HL_A |
| Organism: | Homo sapiens, Plasmodium falciparum 3D7 |
| Method: | XRD |
| Resolution (Å): | 1.76 |
| Reference: | 10.1371/journal.ppat.1010409 |
| Antibody | |
| Antibody: | Fab1512 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | C-terminal alpha-TSR domain of P. falciparum |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7RXP_H|Chain B[auth H]|Fab1512 heavy chain|Homo sapiens (9606) KVQLVQSGGGVVQPGRSQRLSCAASGLTLSEYAMHWVRQAPGKGLEWVAVILSDGTKKEYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCATDDNILGHCRSKSCQRNYYHGMDVWGQGTTVSVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >7RXP_L|Chain A[auth L]|Fab1512 light chain|Homo sapiens (9606) DIVMTQSPLSLPVTPGEPASISCRSSQSLLHSNGKNYLDWYLQKPGQSPQLLIYLGSDRASGVPDRFSGSGSGTDFTLSISRVEAEDVGVYYCMQALQTPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7RXP_A|Chain C[auth A]|Circumsporozoite protein|Plasmodium falciparum (isolate 3D7) (36329) EEPSDKHIKEYLNKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYANDIEKKICKMEKCS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: LYS30 TYR49 LEU50 ASP53 ARG54 ALA55 SER56 H: SER30 GLU31 TYR32 SER52 ASP53 ASP96 ILE98 LEU99 ASP101 A: GLU309 GLU310 PRO311 SER312 ASP313 ILE316 TRP331 ASN340 ILE342 GLN343 ARG345 LYS347 PRO348 GLY349 TYR360 ALA361 ASN362 GLU365 LYS366 LYS367 ILE368 CYS369 LYS370 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
