Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4801 |
| PDBID: | 7RXL |
| Chains: | HL_E |
| Organism: | Homo sapiens, Plasmodium falciparum 3D7 |
| Method: | XRD |
| Resolution (Å): | 1.82 |
| Reference: | 10.1371/journal.ppat.1010409 |
| Antibody | |
| Antibody: | Fab1488 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | C-terminal alpha-TSR domain of P. falciparum |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7RXL_H|Chain B[auth C], D[auth H]|Fab1488 heavy chain|Homo sapiens (9606) EVHLVESGGGLVKPGGSLRLSCAASGFTFSSYTMNWVRQAPGKGLEWVSSISSSSTYIYYADSVRGRFTISRDNAKNSLYLQMNSLRAEDSAVYYCARRAGGFDAYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >7RXL_L|Chain A[auth D], C[auth L]|Fab1488 light chain|Homo sapiens (9606) SYELTQPPSVSVSPGQTASITCSGDKLGDKFACWYQQKPGQSPVLVIYQDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLVSDFYPGAVTVAWKADGSPVKVGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCRVTHEGSTVEKTVAPAECS |
Antigen
Chain: E
Mutation: NULL
| >7RXL_E|Chain E, F|Circumsporozoite protein|Plasmodium falciparum (isolate 3D7) (36329) EPSDKHIKEYLNKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYANDIEKKICKMEKCS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: GLY29 ASP30 LYS31 PHE32 GLN50 ASP51 ASN66 H: SER31 TYR32 THR33 SER52 SER53 THR55 TYR56 ARG95 GLY97 GLY98 PHE99 E: LYS314 LYS317 GLU318 LEU320 ASN321 GLN324 LEU327 LYS353 PRO354 LYS355 ASP356 GLU357 LEU358 ASP359 TYR360 ILE364 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
