Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4799 |
| PDBID: | 7RXJ |
| Chains: | AB_G |
| Organism: | Homo sapiens, Plasmodium falciparum 3D7 |
| Method: | XRD |
| Resolution (Å): | 2.35 |
| Reference: | 10.1371/journal.ppat.1010409 |
| Antibody | |
| Antibody: | Fab236 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | C-terminal alpha-TSR domain of P. falciparum |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7RXJ_A|Chain B[auth A], D[auth H]|Fab236 heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCVASGFNFTTYSMNWVRQAPGKGLEWVSYISSHSNLIYYATSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCARGGSLHPSAGADWIDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: B
Mutation: NULL
| >7RXJ_B|Chain A[auth B], C[auth L]|Fab236 light chain|Homo sapiens (9606) SYELTQAPSVSVSPGQTATITCSGDKLGDKFTSWYQQKPGQSPVLVIYQDSKRPSGIPERFSASNSGNTATLTISGTRAMDEADYYCQAWDSNTYVFGTGTRVAVLSQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: G
Mutation: NULL
| >7RXJ_G|Chain E[auth G], F[auth I]|Circumsporozoite protein|Plasmodium falciparum (isolate 3D7) (36329) EPSDKHIKEYLNKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYANDIEKKICKMEKCS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: GLY29 ASP30 LYS31 PHE32 GLN50 ASP51 ASN66 A: THR31 SER33 TYR50 SER52 HIS53 ASN55 LEU56 GLY96 SER97 LEU98 HIS99 G: LYS314 LYS317 GLU318 LEU320 ASN321 GLN324 LEU327 PRO354 LYS355 ASP356 GLU357 LEU358 ASP359 TYR360 ILE364 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
