Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4798 |
| PDBID: | 7RXI |
| Chains: | HL_A |
| Organism: | Homo sapiens, Plasmodium falciparum 3D7 |
| Method: | XRD |
| Resolution (Å): | 2.15 |
| Reference: | 10.1371/journal.ppat.1010409 |
| Antibody | |
| Antibody: | Fab234 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | C-terminal alpha-TSR domain of P. falciparum |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7RXI_H|Chain B[auth H]|Fab234 heavy chain|Homo sapiens (9606) EVQLVESGGGLVKPGGSLRLSCAASGFNFSTHIMNWVRQAPGKGLEWVSSISSSGTYIYYADSMKGRFTISRDNPKNSLYLQMNSLRAEDTAVYYCARARGFIQFHYYMDVWGKGTTVAVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >7RXI_L|Chain A[auth L]|Fab234 light chain|Homo sapiens (9606) SYVLTQPPSVSVAPGKTARITCGGNNIGSKSVHWHQQRPGQAPVLVVYDDKIRPSGIPERFSGSNSGNTATLIISRVEAGDEADYYCQVWHSSSDPVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLVSDFYPGAVTVAWKADGSPVKVGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCRVTHEGSTVEKTVAPAECS |
Antigen
Chain: A
Mutation: NULL
| >7RXI_A|Chain C[auth A]|Circumsporozoite protein|Plasmodium falciparum (isolate 3D7) (36329) EPSDKHIKEYLNKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYANDIEKKICKMEKCS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: GLY29 SER30 LYS31 SER32 TYR49 ASP50 ASP51 LYS52 ILE53 TRP91 H: THR31 ILE33 SER52 SER53 THR55 TYR56 ARG96 GLY97 PHE98 ILE99 A: LYS314 HIS315 LYS317 GLU318 LEU320 ASN321 LYS322 GLN324 ASN325 LEU327 LYS353 PRO354 LYS355 ASP356 GLU357 LEU358 ASP359 TYR360 ILE364 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
