Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4758 |
| PDBID: | 7RFC |
| Chains: | AB_C |
| Organism: | Homo sapiens, Hepacivirus hominis |
| Method: | XRD |
| Resolution (Å): | 3.24 |
| Reference: | 10.1016/j.immuni.2021.12.003 |
| Antibody | |
| Antibody: | 1382_01_H05 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hepatitis C virus envelope glycoprotein E2 ectodomain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7RFC_A|Chain A, E[auth H]|mAb1382 Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCTTSGGSFGRDAVSWVRQAPGQGLEPMGGIIPIFGTSSYAQTFQGRVTFTAGKSTSTAYMELSSLKSEDTAVYYCVRWSFGDYGLFLTEGDYWGQGTLVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHH |
Light Chain: B
Mutation: NULL
| >7RFC_B|Chain B, F[auth L]|mAb1382 Light Chain|Homo sapiens (9606) EIVLTQSPASLSLSPGERATLSCRASQSVDKYFAWYQQKPGQAPRLLIYETSKRATGIPARFSGSGSGTDFTLTISNLEPDDFAIYYCHHRGNWPPSFTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >7RFC_C|Chain C, D|envelope glycoprotein E2|Hepacivirus C (3052230) STHVTGGTASHTTRHFASLFSSGASQRVQLINTNGSWHINRTALNCNDSLHTGFLAALFYTHKFNASGCPERMAHCRPIDEFAQGWGPITYAEGHGSDQRPYCWHYAPRQCGTIPASQVCGPVYCFTPSPVVVGTTDRFGAPTYTWGENETDVLILNNTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGVGNNTLTCPTDCFRKHPEATYTKCGSGPWLTPRCLVDYPYRLWHYPCTVNFTIFKVRMYVGGVEHRLNAACN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: SER28 GLY30 ARG31 ILE53 PHE54 THR56 LYS73 SER74 PHE97 GLY98 ASP99 B: ASP30 GLY92 ASN93 TRP94 C: HIS421 ILE422 THR425 LEU427 ASN428 CYS429 ASN430 LEU438 ALA439 ALA440 LEU441 PHE442 TYR443 THR444 HIS445 LYS446 PHE447 PRO505 TYR507 VAL515 TRP529 GLU531 PRO612 TYR613 LEU615 TRP616 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
