Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4756 |
| PDBID: | 7RFB |
| Chains: | AB_C |
| Organism: | Homo sapiens, Hepacivirus hominis |
| Method: | XRD |
| Resolution (Å): | 2.70 |
| Reference: | 10.1016/j.immuni.2021.12.003 |
| Antibody | |
| Antibody: | 1198_05_G10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hepatitis C virus envelope glycoprotein E2 ectodomain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7RFB_A|Chain A, E[auth H]|mAb1198 Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCRTSGGTVNTLHWVRQAPGQGLEWMGSIFPLLGVPTYAQKFQGRVTVTADRSTSTAYMELRSLRADDTAVYYCAKDGVGWSGHGPSQWSGVDVWGPGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHH |
Light Chain: B
Mutation: NULL
| >7RFB_B|Chain B, F[auth L]|mAb1198 Light Chain|Homo sapiens (9606) DIVMTQSPLSLPVTPGEPASISCTSSQSLLHSTGYNYLDWYVQKPGQSPQLLIYLGSIRASGVPDRFSGSGSGTDFTLRISRVEAGDVGIYYCMQALEIPRLTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >7RFB_C|Chain C, D|envelope glycoprotein E2|Hepacivirus C (3052230) STHVTGGTASHTTRHFASLFSSGASQRVQLINTNGSWHINRTALNCNDSLHTGFLAALFYTHKFNASGCPERMAHCRPIDEFAQGWGPITYAEGHGSDQRPYCWHYAPRQCGTIPASQVCGPVYCFTPSPVVVGTTDRFGAPTYTWGENETDVLILNNTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGVGNNTLTCPTDCFRKHPEATYTKCGSGPWLTPRCLVDYPYRLWHYPCTVNFTIFKVRMYVGGVEHRLNAACN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: VAL29 ASN30 THR31 LEU53 LEU54 VAL56 GLN64 ARG73 ASP95 GLY96 TRP99 B: SER27 THR28 TYR32 ALA91 LEU92 GLU93 ILE94 ARG95 C: TRP420 ILE422 THR425 LEU427 CYS429 ASN430 ASP431 HIS434 GLY436 LEU438 ALA439 ALA440 LEU441 PHE442 TYR443 THR444 HIS445 LYS446 PHE447 PRO505 TYR507 TRP529 GLU531 PRO612 TYR613 VAL622 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
