Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4749 |
| PDBID: | 7RDW |
| Chains: | UV_D |
| Organism: | Human immunodeficiency virus 1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.55 |
| Reference: | 10.1126/sciadv.abm3948 |
| Antibody | |
| Antibody: | FH1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 HxB2 gp120 core |
| Antigen mutation: | No |
| Durg Target: | P12488; P35961; |
Sequence information
Antibody
Heavy Chain: U
Mutation: NULL
| >7RDW_U|Chain C[auth G], K[auth U]|FH1 Fab Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMNWVRQAPGQGLEWMGWINPNSGDTNYAQKFQGRVTMTRDTSSSTAYMELNRVRSDDTAVYYCARWDWGQYWFFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: V
Mutation: NULL
| >7RDW_V|Chain E[auth I], F[auth L], J[auth R], L[auth V]|FH1 Fab Light Chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATLSCRASQSVRSSYLAWYQQKPGQVPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHMYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: D
Mutation: NULL
| >7RDW_D|Chain A[auth C], B[auth D], G[auth M], H[auth N]|Glycoprotein 120|Human immunodeficiency virus 1 (11676) VWKEATTTLFCASDAKAYDTECHNVWATHACVPTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQCLKPCVKLTNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSVNFTDNAKTIIVQLNTSVEINCTRPNNGGSGSGGNMRQAHCNISRAKWNNTLKQIASKLREQFGNNKTIIFKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWSTEGSNNTEGSDTITLPCRIKQIINMWQKVGKAMYAPPISGQIRCSSNITGLLLTRDGGNSNNESEIFRPGGGDMRDNWRSELYKYKVVKIEPLGSGSGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| U: THR30 GLY31 TYR33 TRP47 TRP50 ASN53 ASP56 THR57 ASN58 TYR59 ALA60 GLN61 GLN64 TRP95 TRP97 GLY98 GLN99 V: GLU1 ILE2 SER27 ARG29 TYR32 HIS90 MET91 TYR96 THR97 D: THR51 PHE53 ALA55 ASP57 ALA58 LYS59 ALA60 TYR61 ASP62 THR63 VAL68 THR71 HIS72 ALA73 CYS74 VAL75 PRO76 THR77 ASP78 PRO79 ASN80 GLU106 ASP107 SER110 GLN114 CYS218 PRO220 ALA221 GLN246 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
