Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4720 |
| PDBID: | 7R6X |
| Chains: | CD_R |
| Organism: | Homo sapiens, Severe acute respiratory syndrome coronavirus 2 |
| Method: | XRD |
| Resolution (Å): | 2.95 |
| Reference: | 10.1038/s41586-021-03807-6 |
| Antibody | |
| Antibody: | S2E12 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 Spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2; P0DTC2; P0DTC2; |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >7R6X_C|Chain G[auth C]|Monoclonal antibody S2E12 Fab heavy chain|Homo sapiens (9606) QVQLVQSGPEVKKPGTSVRVSCKASGFTFTSSAVQWVRQARGQRLEWVGWIVVGSGNTNYAQKFHERVTITRDMSTSTAYMELSSLRSEDTAVYYCASPYCSGGSCSDGFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: D
Mutation: NULL
| >7R6X_D|Chain F[auth D]|Monoclonal antibody S2E12 Fab light chain|Homo sapiens (9606) DIVLTQTPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYVGLTGWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: R
Mutation: NULL
| >7R6X_R|Chain C[auth R]|Spike protein S1|Severe acute respiratory syndrome coronavirus 2 (2697049) ETGTRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTHHHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: SER32 TYR33 TYR92 GLY94 LEU95 TRP98 C: THR30 SER31 SER32 ALA33 TRP50 VAL52 GLY54 SER55 ASN57 MET74 PRO99 GLY104 SER105 CYS106 SER107 ASP108 GLY109 PHE110 R: LYS417 TYR453 LEU455 PHE456 LYS458 TYR473 ALA475 GLY476 SER477 THR478 PRO479 CYS480 GLU484 GLY485 PHE486 ASN487 CYS488 TYR489 PHE490 GLN493 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
