Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4715 |
| PDBID: | 7R58 |
| Chains: | HL_A |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1182/bloodadvances.2022007863 |
| Antibody | |
| Antibody: | Glenzocimab Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Glenzocimab(Phase-II/III) |
| Antigen | |
| Antigen: | Human platelet glycoprotein VI (GPVI) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7R58_H|Chain B[auth H]|Fab heavy chain|Mus musculus (10090) QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYNMHWVRQAPGQGLEWMGGIYPGNGDTSYNQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGTVVGDWYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH |
Light Chain: L
Mutation: NULL
| >7R58_L|Chain C[auth L]|Fab light chain|Mus musculus (10090) DIQMTQSPSSLSASVGDRVTITCRSSQSLENSNGNTYLNWYQQKPGKAPKLLIYRVSNRFSGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCLQLTHVPWTFGQGTKVEITRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7R58_A|Chain A|Platelet glycoprotein VI|Homo sapiens (9606) HHHHHHSSGVDLGTENLYFQSQSGPLPKPSLQALPSSLVPLEKPVTLRCQGPPGVDLYRLEKLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQLELVATGVFAKPSLSAQPGPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERWYRASFPIITVTAAHSGTYRCYSFSSRDPYLWSAPSDPLELVVT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: GLY26 THR28 THR30 SER31 ASN33 TYR52 ASN55 ASP57 THR100 VAL101 VAL102 GLY103 ASP104 TRP105 TYR106 L: ASN31 ASN33 ASN35 TYR37 TYR54 ARG55 ASN58 ARG59 PHE60 SER61 LEU96 THR97 VAL99 TRP101 A: ASP81 GLN99 PRO100 GLY108 ASP109 THR111 LEU125 PRO131 ALA132 PRO133 TYR134 LYS135 ASN136 PRO137 GLU138 ARG139 SER144 PHE145 PRO146 ILE147 ILE148 THR149 THR151 ALA153 HIS154 TYR158 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
