Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4711 |
| PDBID: | 7R1Z |
| Chains: | C_A |
| Organism: | Vicugna pacos, Rattus norvegicus |
| Method: | XRD |
| Resolution (Å): | 1.94 |
| Reference: | 10.1371/journal.pone.0269281 |
| Antibody | |
| Antibody: | C11 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | collapsed human Activity-regulated cytoskeleton-associated protein (hArc) CTD |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >7R1Z_C|Chain C|NbArc-C11|Vicugna pacos (30538) GSEVQLVESGGGLVQAGGSLRLSCAASGRTSGALNVAWYRQATGKEREYVARLWWNDGTTYYSDSVKGRFTISSDNAKKIVYLQMNRLKPDDTAIYYCAVRTPSSQTLYWGQGTQVTVSS |
Antigen
Chain: A
Mutation: NULL
| >7R1Z_A|Chain B[auth A]|Activity-regulated cytoskeleton-associated protein|Rattus norvegicus (10116) MHHHHHHLESTSLYKKAGSENLYFQSPGVDTQIFEDPREFLSHLEEYLRQVGGSEEYWLSQIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSEGTLSREAIQRELDLPQKQGEPLDQFLWRKRDLYQTLYVDADEEEIIQYVVGTLQPKLKRFLRHPLPKTLEQLIQRGMEVQDDLEQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: LEU34 ASN35 TYR39 TYR49 ARG52 TRP54 ASP57 THR59 TYR61 ARG101 THR102 PRO103 SER104 SER105 GLN106 THR107 LEU108 TRP110 A: ARG281 GLN285 LEU288 TYR309 LEU312 TYR313 VAL314 ASP315 ALA316 ASP317 GLU319 GLU320 GLN323 TYR324 VAL326 GLY327 GLN330 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
