Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4709 |
| PDBID: | 7QU2 |
| Chains: | AB_C |
| Organism: | Mus musculus, Mammarenavirus juninense |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1128/mbio.02650-21 |
| Antibody | |
| Antibody: | JUN1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Junin virus glycoprotein G1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7QU2_A|Chain A|Fab JUN1 heavy chain|Mus musculus (10090) ETGQIQLVQSVETGGGLVRPGNSLKLSCVTSGFTFSNYQMHWLRQPPGKRLEWIAVITVKSDNYGANYVESVKGRFAISRDDSKSSVYLEMNRLREEDTATYFCSRSGIYDGYYAYAMDYWGQGTSVTVSSATTKGPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRDCGTKHHHHHH |
Light Chain: B
Mutation: NULL
| >7QU2_B|Chain B|Fab JUN1 light chain|Mus musculus (10090) ETGSVVMTQSQKFMSTSVGDRVSITCKASQIVGTSVAWYQQKAGQSPKLLIYWASTRHTGVPDRFTAGGSGTDFTLTITNVQSEDLADYFCQQYATYPLTFGSGTKLELKRTDAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: C
Mutation: NULL
| >7QU2_C|Chain C|Glycoprotein G1|Argentinian mammarenavirus (2169991) ETGDLPLLCTLNKSHLYIKGGNASFQISFDDIAVLLPQYDVIIQHPADMSWCSKSDDQIWLSQWFMNAVGHDWHLDPPFLCRNRTKTEGFIFQVNTSKTGVNENYAKKFKTGMHHLYREYPDSCLNGKLCLMKAQPTSWPLQCPLDHVNKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: GLN33 VAL50 ASP53 ASN54 GLY56 ALA57 ASN58 ILE97 ASP99 B: VAL2 GLN27 ILE28 VAL29 GLY30 THR31 SER32 TRP50 TYR91 ALA92 THR93 TYR94 C: SER111 ASP113 ILE115 ALA116 VAL117 LEU119 GLN121 TYR122 ASP123 LYS137 ARG165 THR168 LYS169 THR170 GLU171 ILE174 LYS216 GLN218 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
