Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4708 |
| PDBID: | 7QU1 |
| Chains: | AB_C |
| Organism: | Mus musculus, Mammarenavirus machupoense |
| Method: | XRD |
| Resolution (Å): | 1.91 |
| Reference: | 10.1128/mbio.02650-21 |
| Antibody | |
| Antibody: | MAC1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Pre-glycoprotein polyprotein GP complex |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7QU1_A|Chain A|Fab MAC1 heavy chain|Mus musculus (10090) ETGQVQLQQSGAELVKPGASVKISCKASGYAFGSHWMNWVKQRPGKGLEWIGQIYPGDGDTNYNGKFKGKATLTADKSSSTAYMQFSSLTSEDSAVYFCARDDYGTRYYFDYWGQGTTLTVSSATTKGPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRDCGTKHHHHHH |
Light Chain: B
Mutation: NULL
| >7QU1_B|Chain B|Fab MAC1 light chain|Mus musculus (10090) ETGDIQMTQTTSSLSASLGDRVSISCRASQDINNYLNWYQQKPDGTVKLLIHYTSRLRSGVPSRFSGSGFGTDYSLTITNLEQEDIATYFCQQGKTLPLTFGAGTKLEIKRTDAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: C
Mutation: NULL
| >7QU1_C|Chain C|Pre-glycoprotein polyprotein GP complex|Machupo mammarenavirus (3052317) ELPSLCMLNNSFYYMKGGANIFLIRVSDVSVLMKEYDVSVYEPEDLGNCLNKSDSSWAIHWFSIALGHDWLMDPPMLCRNKTKKEGSNIQFNISKADESRVYGKKIRNGMRHLFRGFYDPCEEGKVCYVTINQCGDPSSFEYCGTNYLSKCQFDHVNTLHFLVRSKTHLNFGTGTKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ALA28 SER31 TRP33 ASP54 ASP56 TYR97 GLY98 THR99 B: TYR32 ASN34 HIS49 TYR50 ARG53 C: VAL117 MET119 GLU121 TYR122 ASP123 ARG165 LYS169 LYS170 GLU171 PRO223 SER224 PHE226 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
