Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4698 |
| PDBID: | 7QNX |
| Chains: | AB_E |
| Organism: | Homo sapiens, Severe acute respiratory syndrome coronavirus 2 |
| Method: | XRD |
| Resolution (Å): | 2.92 |
| Reference: | 10.1016/j.cell.2021.12.046 |
| Antibody | |
| Antibody: | Beta-55 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 spike glycoprotein |
| Antigen mutation: | Yes |
| Durg Target: | P0DTC2; P0DTC2; |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7QNX_A|Chain C[auth A]|Beta-55 heavy chain|Homo sapiens (9606) QVQLQESGPGLVKPSETLSLTCTVSGDSISSSRYYWGWIRQPPGKGLEWIGTFYYSGITYYNPSLKSRVTIFVDTSKNQFSLKLSSVTAADTAVYYCARPRPPDYYDNSGALLFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK |
Light Chain: B
Mutation: NULL
| >7QNX_B|Chain D[auth B]|Beta-55 light chain|Homo sapiens (9606) AIRMTQSPSTLSASVGDRVTIACRASQSISAWLAWYQQKPGKAPKLLIYKASSLESGVPSRFSGSGSGTEFTLTINSLQPDDFATYYCQQYISSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: P202K
| >7QNX_E|Chain E|Surface glycoprotein|Severe acute respiratory syndrome coronavirus 2 (2697049) HHHHHHTNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGKK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TYR35 TYR54 TYR55 SER56 ILE58 THR59 TYR60 PRO103 ASP104 TYR105 TYR106 ASP107 ASN108 SER109 GLY110 ALA111 LEU112 B: SER93 SER94 E: GLY404 ASP405 ARG408 ASN437 ASN439 ASN440 LEU441 SER443 LYS444 VAL445 GLN498 PRO499 THR500 ASN501 GLY502 VAL503 GLY504 TYR505 GLN506 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
