Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4661 |
| PDBID: | 7Q6C |
| Chains: | HL_A |
| Organism: | Homo sapiens, Mus musculus, Lama glama |
| Method: | XRD |
| Resolution (Å): | 2.29 |
| Reference: | 10.1159/000524587 |
| Antibody | |
| Antibody: | CP010 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human complement component C6 FIM1-2 |
| Antigen mutation: | Yes |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7Q6C_H|Chain B[auth H]|CP010 heavy chain|Mus musculus (10090) EVQLVESDGGLVQPGGSLKLSCAASGFTFSDYYMAWVRQGPGKGLEWVATINYDGSSTYYRESVKGRFTISRDNAKNTLYLQMNSLRAEDTATYYCARPSTEALFAYWGHGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESS |
Light Chain: L
Mutation: NULL
| >7Q6C_L|Chain D[auth L]|CP010 light chain|Mus musculus (10090) DVVLTQTPSTLSVTPGQPASISCRSSQSLLNDVGNTYLYWYLQKPGQSPQLLIYLVSDLGSGVPNRFSGSGSGTDFTLKISRVEAEDVGIYYCMQASHAPYTFGQGTNLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: N87A
| >7Q6C_A|Chain A|Complement component C6|Homo sapiens (9606) LKGHCQLGQKQSGSECICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDGRQLEWGLERTRLSSASTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKMGSSTSEKTLNICEVGTIRCANRKMEILHPGKCLA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: THR28 SER30 ASP31 TYR32 TYR33 THR50 ASN52 TYR53 SER56 SER57 TYR59 PRO99 SER100 THR101 GLU102 ALA103 LEU104 L: ASP32 VAL33 GLY34 ASN35 TYR37 TYR39 TYR54 LEU55 SER57 ASP58 ALA96 TYR101 A: ARG841 GLN842 TRP845 LYS872 CYS873 SER874 ALA875 SER876 THR877 LYS879 VAL881 CYS882 LEU883 LEU884 PRO885 PRO886 GLN887 CYS888 PHE889 LYS890 GLY891 LYS907 THR908 LEU909 ASN910 GLU913 CYS919 ASN921 ARG922 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
