Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4660 |
| PDBID: | 7Q3R |
| Chains: | G_A |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 1.92 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | G09 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2; P0DTC2; |
Sequence information
Antibody
Chain: G
Mutation: NULL
| >7Q3R_G|Chain C[auth G]|VHH-G09|Vicugna pacos (30538) AMAEVQLVESGGGTVQPGGSLRLSCEVSGTGFTINAMGWDRQAPGKQRELVATITRGDRIHYADSVKGRFAISRDKDKNTVYLEMNNLKPEDTAVYYCDVAAFDSSDYEVLDSWGQGTQVTVSSAAAHHHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >7Q3R_A|Chain A|Spike glycoprotein|Severe acute respiratory syndrome coronavirus 2 (2697049) NITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSFLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: GLU1 THR30 ASN32 ALA33 ASP37 GLN44 ARG45 GLU46 LEU47 THR50 THR52 ARG53 GLY54 ARG56 HIS58 TYR59 ALA60 ASP96 ALA98 PHE100 SER102 ASP104 TYR105 GLU106 VAL107 LEU108 ASP109 TRP111 A: ARG346 PHE347 ALA348 SER349 TYR351 ALA352 TRP353 ASN354 ARG355 LYS444 VAL445 GLY446 GLY447 TYR449 ASN450 TYR451 LEU452 ARG466 ILE468 THR470 GLU484 PHE490 LEU492 GLN493 SER494 PRO499 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
