Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4611 |
| PDBID: | 7PI3 |
| Chains: | ab_V |
| Organism: | Plasmodium falciparum 3D7, Gallus gallus |
| Method: | XRD |
| Resolution (Å): | 3.27 |
| Reference: | 10.1038/s41467-022-28601-4 |
| Antibody | |
| Antibody: | Cy.004 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Cysteine-rich protective antigen |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: a
Mutation: NULL
| >7PI3_a|Chain AA[auth F], F[auth M], M[auth T], T[auth a]|Monoclonal antibody Cy.004 heavy chain|Gallus gallus (9031) AVTLDESGGGLQTPGGALSLVCKASGFDFSSYAMGWVRQAPGKGLEYVAGIRNDGSFTLYTPAVKGRATISRDNGQSTVRLQLNNLRAEDTATYFCTKSADDGGHYSDFSGEIDAWGHGTEVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQD |
Light Chain: b
Mutation: NULL
| >7PI3_b|Chain BA[auth G], G[auth N], N[auth U], U[auth b]|Monoclonal antibody Cy.004 light chain|Gallus gallus (9031) ALTQPSSVSANPGETVKITCSGSTYNYGWYQQKSPGSAPVTVIYYNDKRPSDIPSRFSGSKSGSTGTLTITGVQAEDEAVYYCGNSDSRNVAFGAGTTLTVLRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: V
Mutation: NULL
| >7PI3_V|Chain A, H, O, V|Cysteine-rich protective antigen|Plasmodium falciparum 3D7 (36329) DSRHVFIRTELSFIKNNVPCIRDMFFIYKRELYNICLDDLKGEEDETHIYVQKKVKDSWITLNDLFKETDLTGRPHIFAYVDVEEIIILLCEDEEFSNRKKDMTCHRFYSNDGKEYNNAEITISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKDDNKKDDILCMASHDKGETWGTKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGDNINNVKNVNFIECTHEKDLEFVCSNRDFLKDNKVLQDVSTLNDEYIVSYGNDNNFAECYIFFNNENSILIKPEKYGNTAAGCYGGTFVKIDENRALFIYSSSQGIYNIHTIYYANYEGGGGSEPEA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| a: SER49 ARG71 ASN72 ASP73 PHE76 ASN93 ASP120 ASP121 GLY122 GLY123 HIS124 TYR125 SER126 b: TYR47 TYR67 SER108 ARG111 V: PHE94 LYS95 GLU96 THR97 ASP98 LEU99 THR100 GLU120 GLU123 PHE124 ASN126 LYS128 THR132 HIS134 ASN146 GLU148 THR150 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
