Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4607 |
| PDBID: | 7PI3 |
| Chains: | DE_A |
| Organism: | Plasmodium falciparum 3D7, Gallus gallus |
| Method: | XRD |
| Resolution (Å): | 3.27 |
| Reference: | 10.1038/s41467-022-28601-4 |
| Antibody | |
| Antibody: | Cy.007 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Cysteine-rich protective antigen |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >7PI3_D|Chain D, K, R, Y|Monoclonal antibody Cy.007 heavy chain|Gallus gallus (9031) AVTLDESGGGLQTPGGTLSLVCKGSGFTFSSYEMQWVRQAPGKGLEWVADICIGGSYTGYGPAVKGRATISRDDGQSTVRLQLNNLRAEDTGTYYCAKTARSDYCITGLDDIDAWGHGTEVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK |
Light Chain: E
Mutation: NULL
| >7PI3_E|Chain E, L, S, Z|Monoclonal antibody Cy.007 light chain|Gallus gallus (9031) ALTQPSSVSANPGETVKITCSGGSSDYGWYQQKSPGSAPVTVIYENNKRPSDIPSRFSGSKFGSTHTLTITGVQADDEAVYFCGSRDTNNGAFGAGTTLTVLRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7PI3_A|Chain A, H, O, V|Cysteine-rich protective antigen|Plasmodium falciparum 3D7 (36329) DSRHVFIRTELSFIKNNVPCIRDMFFIYKRELYNICLDDLKGEEDETHIYVQKKVKDSWITLNDLFKETDLTGRPHIFAYVDVEEIIILLCEDEEFSNRKKDMTCHRFYSNDGKEYNNAEITISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKDDNKKDDILCMASHDKGETWGTKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGDNINNVKNVNFIECTHEKDLEFVCSNRDFLKDNKVLQDVSTLNDEYIVSYGNDNNFAECYIFFNNENSILIKPEKYGNTAAGCYGGTFVKIDENRALFIYSSSQGIYNIHTIYYANYEGGGGSEPEA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: ASP69 CYS71 ILE72 GLY73 SER75 TYR76 ASP93 ARG120 SER121 ASP122 TYR123 CYS124 ILE125 THR126 E: ASP48 ASN69 LYS70 LYS83 ARG108 ASN111 A: LYS43 ASN45 VAL46 ASP66 GLU72 HIS76 TYR78 LYS81 VAL83 LYS84 SER86 TRP87 ILE88 THR89 LEU90 ASN91 ASP92 LYS95 GLU96 ASP140 LYS142 ASN145 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
