Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4599 |
| PDBID: | 7PI2 |
| Chains: | BC_A |
| Organism: | Plasmodium falciparum 3D7, Gallus gallus |
| Method: | XRD |
| Resolution (Å): | 3.14 |
| Reference: | 10.1038/s41467-022-28601-4 |
| Antibody | |
| Antibody: | Cy.003 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Cysteine-rich protective antigen |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >7PI2_B|Chain B, E, H, K|Monoclonal antibody Cy.003 heavy chain|Gallus gallus (9031) AVTLDESGGGLQTPGGALSLVCKGSGFFSFSSYTMQWVRQAPGKGLEWVASISSGGGTNYGAAVKGRATISRDNGQSTLRLQLNNLRAEDTGTYYCAKHGVNGCDWSYSVGCVDAWGHGTEVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK |
Light Chain: C
Mutation: NULL
| >7PI2_C|Chain C, F, I, L|Monoclonal antibody Cy.003 light chain|Gallus gallus (9031) ALTQPSSVSANPGETVKITCSGGSSSYYGWYQQKSPGSAPVTLIYNNQKRPSDIPSRFSGSKSGSTGTLTITGVQAEDEAVYFCGSRDNSGGIFGAGTTLTVLRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7PI2_A|Chain A, D, G, J|Cysteine-rich protective antigen|Plasmodium falciparum (isolate 3D7) (36329) DSRHVFIRTELSFIKNNVPCIRDMFFIYKRELYNICLDDLKGEEDETHIYVQKKVKDSWITLNDLFKETDLTGRPHIFAYVDVEEIIILLCEDEEFSNRKKDMTCHRFYSNDGKEYNNAEITISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKDDNKKDDILCMASHDKGETWGTKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGDNINNVKNVNFIECTHEKDLEFVCSNRDFLKDNKVLQDVSTLNDEYIVSYGNDNNFAECYIFFNNENSILIKPEKYGNTAAGCYGGTFVKIDENRALFIYSSSQGIYNIHTIYYANYEGGGGSEPEA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: SER50 SER51 SER72 SER73 GLY74 GLY76 ASN78 ASN121 GLY122 CYS123 ASP124 TRP125 SER126 TYR127 C: SER46 SER47 SER48 TYR49 ASN69 LYS84 GLY86 ARG109 ASN111 A: GLU113 ARG135 TYR137 ASN139 GLU143 ASN145 ASN146 ALA147 ILE149 ARG174 HIS202 ASP203 LYS204 GLU206 THR207 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
