Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4597 |
| PDBID: | 7PHW |
| Chains: | BC_A |
| Organism: | Plasmodium falciparum 3D7, Gallus gallus |
| Method: | XRD |
| Resolution (Å): | 2.79 |
| Reference: | 10.1038/s41467-022-28601-4 |
| Antibody | |
| Antibody: | Cy.004 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Cysteine-rich protective antigen |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >7PHW_B|Chain B, E|Monoclonal antibody Cy.004 heavy chain|Gallus gallus (9031) AVTLDESGGGLQTPGGALSLVCKASGFDFSSYAMGWVRQAPGKGLEYVAGIRNDGSFTLYTPAVKGRATISRDNGQSTVRLQLNNLRAEDTATYFCTKSADDGGHYSDFSGEIDAWGHGTEVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQD |
Light Chain: C
Mutation: NULL
| >7PHW_C|Chain C, F|Monoclonal antibody Cy.004 light chain|Gallus gallus (9031) ALTQPSSVSANPGETVKITCSGSTYNYGWYQQKSPGSAPVTVIYYNDKRPSDIPSRFSGSKSGSTGTLTITGVQAEDEAVYYCGNSDSRNVAFGAGTTLTVLRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7PHW_A|Chain A, D|Cysteine-rich protective antigen|Plasmodium falciparum (isolate 3D7) (36329) DSRHVFIRTELSFIKNNVPCIRDMFFIYKRELYNICLDDLKGEEDETHIYVQKKVKDSWITLNDLFKETDLTGRPHIFAYVDVEEIIILLCEDEEFSNRKKDMTCHRFYSNDGKEYNNAEITISDYILKDKLLSSYVSLPLKIENREYFLICGVSPYKFKDDNKKDDILCMASHDKGETWGTKIVIKYDNYKLGVQYFFLRPYISKNDLSFHFYVGDNINNVKNVNFIECTHEKDLEFVCSNRDFLKDNKVLQDVSTLNDEYIVSYGNDNNFAECYIFFNNENSILIKPEKYGNTAAGCYGGTFVKIDENRALFIYSSSQGIYNIHTIYYANYEGGGGSEPEA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: SER50 TYR51 ARG71 ASN72 ASP73 SER75 PHE76 LYS84 ALA119 ASP120 ASP121 GLY122 GLY123 HIS124 TYR125 SER126 C: THR46 TYR47 ASN48 TYR67 SER108 SER110 ARG111 A: LYS69 GLU71 GLU72 THR75 PHE94 LYS95 GLU96 THR97 ASP98 LEU99 THR100 GLY101 GLU120 ASP121 GLU122 GLU123 ASN126 LYS128 THR132 HIS134 GLU148 THR150 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
