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Entry information

Complex
AACDB_ID: 459
PDBID: 3EBA
Chains: A_B
Organism: Camelus dromedarius, Homo sapiens
Method: XRD
Resolution (Å): 1.85
Reference: 10.1074/jbc.M806889200
Antibody
Antibody: CAbHul6 Nanobody
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Lysozyme C
Antigen mutation: No
Durg Target: P61626

Sequence information

Antibody

Chain: A
Mutation: NULL

>3EBA_A|Chain A|CAbHul6|Camelus dromedarius (9838)
QVQLVESGGGSVQAGGSLRLSCSASGYTYISGWFRQAPGKGLEWVAAIRSSDGTTYYADSVKGRFTISQDNAKNTVYLQMNSLKPEDTAMYYCAATEVAGWPLDIGIYDYWGQGTQVTVSSHHHHHH

Antigen

Chain: B
Mutation: NULL

>3EBA_B|Chain B|Lysozyme C|Homo sapiens (9606)
KVFERCELARTLKRLGMDGYRGISLANWMCLAKWESGYNTRATNYNAGDRSTDYGIFQINSRYWCNDGKTPGAVNACHLSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNRCQNRDVRQYVQGCGV

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

A: TYR27 TYR29 ARG49 SER51 ASP52 GLU97 VAL98 ALA99 GLY100 TRP101 PRO102 ASP104 GLY106 ILE107 ASP109

B: ARG14 LEU15 GLY16 TYR20 ALA76 CYS77 HIS78 LEU79 ASN88 ALA90 ASP91 VAL93 ALA94 CYS95 LYS97 ARG98 ARG101

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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