Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4589 |
| PDBID: | 7PHG |
| Chains: | HL_A |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 4.30 |
| Reference: | 10.1016/j.celrep.2021.109814 |
| Antibody | |
| Antibody: | P5C3 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 Spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7PHG_H|Chain B[auth H]|Heavy ChaIn variable|Homo sapiens (9606) QMQLVQSGPEVKKPGTSVKVSCKASGFTFTSSAVQWVRQARGQRLEWIGWIVVGSGNTDYAQQFQERVTITRDMSTSTAYMELSSLGSEDTAVYYCAAPNCSGGSCYDGFDLWGQGTMVTVSS |
Light Chain: L
Mutation: NULL
| >7PHG_L|Chain C[auth L]|Light ChaIn|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATLSCRGSQSVRSSYLGWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK |
Antigen
Chain: A
Mutation: NULL
| >7PHG_A|Chain A|Surface glycoprotein|Severe acute respiratory syndrome coronavirus 2 (2697049) ITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR30 SER31 ALA33 TRP50 GLY53 SER54 GLY55 PRO95 GLY99 PHE100 L: ARG29 SER31 TYR32 TYR49 SER52 TYR91 GLY92 SER93 SER94 TRP96 A: LYS417 TYR421 LEU455 PHE456 ARG457 LYS458 SER459 TYR473 GLN474 ALA475 GLY476 SER477 THR478 CYS480 ASN481 VAL483 GLU484 GLY485 PHE486 ASN487 CYS488 TYR489 PHE490 LEU492 GLN493 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
