Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4583 |
| PDBID: | 7PC2 |
| Chains: | OP_B |
| Organism: | Homo sapiens, Human immunodeficiency virus |
| Method: | EM |
| Resolution (Å): | 2.80 |
| Reference: | 10.1084/jem.20212045 |
| Antibody | |
| Antibody: | 7-269 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 BG505 SOSIP.664 envelope glycoprotein- gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: O
Mutation: NULL
| >7PC2_O|Chain A[auth M], C[auth O], E[auth Q]|7-269 IgA Fab heavy chain|Homo sapiens (9606) QMQLVESGGGVVQPGRSLRLSCAASRFDFNRFGMHWVRQAPGKGLEWVAYMSYDGGDRYYADSVKGRFTISRDNSKSTLHLQMDSLRPEDTAVYYCAKDDILGDCSTSHCYWGYYYQGMDVWGHGTTVTVSSASTTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPHHHHHH |
Light Chain: P
Mutation: NULL
| >7PC2_P|Chain B[auth N], D[auth P], F[auth R]|7-269 IgA Fab light chain|Homo sapiens (9606) EIVMTQSPDTLSVSPGERVTLSCRASQSVGSNLVWYQQKPGQSTRVLIYGASTRAATVPARFSGGGSGTEFTLTISSVQSEDFAVYYCYHYNNWPRGSFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >7PC2_B|Chain G[auth A], H[auth B], I[auth C]|gp120, BG505 SOSIP.664 T332N|Human immunodeficiency virus (12721) AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRRR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| O: SER108 HIS109 GLY113 TYR114 TYR115 P: GLY30 SER31 B: ASN295 ASN332 SER334 ASN411 ASP412 SER413 ARG444 VAL446 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
