Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4537 |
| PDBID: | 7OX4 |
| Chains: | AB_C |
| Organism: | Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.80 |
| Reference: | 10.1101/2022.12.30.522308 |
| Antibody | |
| Antibody: | 35D8 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Mouse interleukin-9 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >7OX4_A|Chain A|Heavy chain (Fab 35D8)|Mus musculus (10090) QVQLVESGPGLVQPSQTLSLTCTVSGGSITTSYYDWSWIRQPPGKGLEWMGAIAYSGNAYYSPSLKSRTSISRDTSKNQFTLQLSSVTPEDTAVYYCAREDHYSDTHGWNDYWGQGTQVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: B
Mutation: NULL
| >7OX4_B|Chain B|Light chain (Fab 35D8)|Mus musculus (10090) SSALTQPSAVSVSLGQTARITCQGGSIGNFGATWYQQKPGQAPVLLSLGEHSRPSGIPERFSGSKSGGTATLTISGAQAEDEADYYCQSFDYIGNDHVFGGGTHLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: C
Mutation: NULL
| >7OX4_C|Chain C|Interleukin-9|Mus musculus (10090) GSHMQRCSTTWGIRDTNYLIENLKDDPPSKCSCSGNVTSCLCLSVPTDDCTTPCYREGLLQLTNATQKSRLLPVFHRVKRIVEVLKNITCPSFSCEKPCNQTMAGNTLSFLKSLLGTFQKTEMQRQKSRP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TYR33 ASP35 ALA54 TYR60 HIS102 TYR103 SER104 ASP105 THR106 B: GLY28 ASN29 PHE30 LYS65 PHE90 ASP91 TYR92 ILE93 GLY94 C: CYS21 SER22 THR24 TRP25 ARG28 ASP29 TYR32 GLU35 ASN36 ARG84 PRO87 VAL88 HIS90 ARG91 ARG94 ILE95 VAL98 LEU99 ILE102 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
