Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4536 |
| PDBID: | 7OX3 |
| Chains: | BA_C |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.70 |
| Reference: | 10.1101/2022.12.30.522308 |
| Antibody | |
| Antibody: | 6D3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human Interleukin-9 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >7OX3_B|Chain A[auth B]|Light chain (Fab 6D3)|Homo sapiens (9606) LSYELTQPSALSVTLGQTAKITCQGGSLGSSYAHWYQQKPDQAPILVIYDDDSRPSGIPERFSGSSSGGTATLTISGAQAEDEGDYYCQSYDSSANFVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Light Chain: A
Mutation: NULL
| >7OX3_A|Chain B[auth A]|Heavy chain (Fab 6D3)|Homo sapiens (9606) QVQVQESGPGLVKPSQTLSLTCTVSGGPITTRYYAWSWIRQPPGKGLEWMGLIDYDGSVYYSPSLKSRTSISRDTAKNQFSLQLSSVTPEDTAVYYCARVSAATLFLDYWGQGTQVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Antigen
Chain: C
Mutation: NULL
| >7OX3_C|Chain C|Interleukin-9|Homo sapiens (9606) GSHMQGCPTLAGILDINFLINKMQEDPASKCHCSANVTSCLCLGIPSDNCTRPCFSERLSQMTNTTMQTRYPLIFSRVKKSVEVLKNNKCPYFSCEQPCNQTTAGNALTFLKSLLEIFQKEKMRGMRGKI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: SER27 GLY29 SER30 SER31 TYR32 ASP51 TYR91 ASP92 SER93 SER94 ALA95 A: ARG32 ALA35 LEU52 ASP54 TYR55 ASP56 SER58 VAL59 TYR60 ALA102 ALA103 THR104 LEU105 C: LEU24 ALA25 LEU28 ASP29 PHE32 GLN82 THR83 ARG84 TYR85 PRO86 LEU87 ILE88 PHE89 SER90 ARG91 LYS94 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
