Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4533 |
| PDBID: | 7OX2 |
| Chains: | BC_O |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.34 |
| Reference: | 10.1101/2022.12.30.522308 |
| Antibody | |
| Antibody: | 6E2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human Interleukin-9 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >7OX2_B|Chain A, D[auth B], G[auth D], J|Heavy chain (Fab 6E2)|Homo sapiens (9606) QVQLVESGGGLVQPGGSLRLSCAASGFTFSSSAMGWVRQAPGKGLEWVSTIVNSITTTYYADSVKGRFTISTDNAKNTLYLQIDSLKSEDTAVYYCGSLAGPYYDYWGQGTQVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: C
Mutation: NULL
| >7OX2_C|Chain B[auth C], E, H[auth K], K[auth L]|Light chain (Fab 6E2)|Homo sapiens (9606) SSALTQPSTVSVSLGQTARITCQGGSLGSYDAHWYQQKPGQAPVLVIHDNNSRPSGIPERFTGSRSGETATLTISGAQTEDEADYYCQSYDSTSDALVFGGGTQLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: O
Mutation: NULL
| >7OX2_O|Chain C[auth M], F[auth N], I[auth O], L[auth T]|Interleukin-9|Homo sapiens (9606) GSHMQGCPTLAGILDINFLINKMQEDPASKCHCSANVTSCLCLGIPSDNCTRPCFSERLSQMTNTTMQTRYPLIFSRVKKSVEVLKNNKCPYFSCEQPCNQTTAGNALTFLKSLLEIFQKEKMRGMRGKI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: THR28 SER31 SER32 ALA33 TRP47 THR50 VAL52 SER54 ILE55 THR56 THR57 THR58 TYR59 LYS65 LEU99 ALA100 GLY101 PRO102 TYR103 C: SER29 TYR30 ASP31 ASP49 ASN50 SER52 TYR90 SER92 ASP95 ALA96 LEU97 O: CYS21 PRO22 THR23 LEU24 ALA25 ILE27 LEU28 ASP29 ASN31 PHE32 ILE34 ASN35 GLN38 LEU87 ILE88 ARG91 LYS94 SER95 VAL98 LEU129 GLU130 GLN133 LYS136 MET137 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
