Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4529 |
| PDBID: | 7OX1 |
| Chains: | HL_X |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.49 |
| Reference: | 10.1101/2022.12.30.522308 |
| Antibody | |
| Antibody: | 7D6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human Interleukin-9 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7OX1_H|Chain A, C, E, H|Heavy chain (Fab 7D6)|Homo sapiens (9606) QLQLVESGPGLVKPSQTLSLTCTVSGGSITTGYYAWSWIRQPPGKGLEWMGFIARDGSTSYSPSLKSRTSISRDTSKNQFSLQLSSVTPEDTAVYYCARAGEGRSWYPGYYYGMDYWGKGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >7OX1_L|Chain B, D, F, I[auth L]|Light chain (Fab 7D6)|Homo sapiens (9606) QAVVTQEPSLSVSPGGTVTLTCGLSSGSVTSSNYPGWYQQTPGQAPRVLIYNTNSRHSGVPSRYSGFISGNKAALTITGAEPEDEADYYCHLHKGSTGVFGGGTHLTVLSQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: X
Mutation: NULL
| >7OX1_X|Chain G, J[auth X], K[auth Y], L[auth Z]|Interleukin-9|Homo sapiens (9606) GSHMQGCPTLAGILDINFLINKMQEDPASKCHCSANVTSCLCLGIPSDNCTRPCFSERLSQMTNTTMQTRYPLIFSRVKKSVEVLKNNKCPYFSCEQPCNQTTAGNALTFLKSLLEIFQKEKMRGMRGKI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR30 TYR33 PHE52 ALA54 ARG55 ASP56 SER58 THR59 SER60 PRO63 ARG73 TRP106 TYR107 TYR110 TYR111 L: LEU24 SER26 SER28 THR30 SER31 SER32 ASN33 TYR34 LYS94 GLY95 SER96 THR97 X: CYS21 PRO22 THR23 LEU24 ALA25 ILE27 LEU28 ASP29 ASN31 PHE32 ASN35 LYS36 GLU39 TYR85 LEU87 ILE88 ARG91 GLN133 LYS136 MET140 LYS143 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
