Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 451 |
| PDBID: | 3D85 |
| Chains: | BA_C |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1016/j.jmb.2008.08.001 |
| Antibody | |
| Antibody: | 7G10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interleukin-23 subunit p19 |
| Antigen mutation: | No |
| Durg Target: | Q9NPF7 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >3D85_B|Chain B|FAB of antibody 7G10, heavy chain|Homo sapiens (9606) EVQLQQSGPELVKPGASVKMSCKASGYTFTSNVMHWVKQKPGQGLEWIGYINPYNDGTKYNEKFKGKATLTSDKSSSTAYMELSSLTSEDSAVYYCARNWDVAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT |
Light Chain: A
Mutation: NULL
| >3D85_A|Chain A|FAB of antibody 7G10, light chain|Homo sapiens (9606) DIVMTQSPATLSVTPGDRVSLSCRASQSISDYLHWYRQKSHESPRLLIKYASQSISGIPSRFSGSGSGSDFTLSINSVEPEDVGVYYCQNGHSFPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >3D85_C|Chain C|Interleukin-23 subunit p19|Homo sapiens (9606) RAVPGGSSPAWTQCQQLSQKLCTLAWSAHPLVGHMDLREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEKLLGSDIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGAATLSPGSHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TYR32 HIS34 TYR50 GLY91 HIS92 SER93 PHE94 PHE96 B: THR30 SER31 ASN32 VAL33 HIS35 TYR50 ASN52 TYR54 ASN55 THR58 LYS59 ASN99 TRP100 ASP101 VAL102 C: GLU82 LYS83 GLY86 SER87 ASP88 THR91 GLY92 GLU93 PRO94 SER95 HIS106 LEU110 LEU131 PRO133 SER134 GLN135 PRO136 TRP137 ARG139 LEU140 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
