Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4505 |
| PDBID: | 7O9S |
| Chains: | HL_A |
| Organism: | Oryctolagus cuniculus, Orthohantavirus hantanense |
| Method: | XRD |
| Resolution (Å): | 2.70 |
| Reference: | 10.1128/mBio.02531-20 |
| Antibody | |
| Antibody: | nnHTN-Gn2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hantaan virus envelope polyprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7O9S_H|Chain A[auth H]|Fab nnHTN-Gn2 Heavy chain|Oryctolagus cuniculus (9986) TGQSLEESGGRLVTPGTPLTLTCTVSGFSLSNYNMQWVRQAPGKGLEWIGIVYTGGVAWYARWAKGRFTISRTSTTVDLKITSPTTEDTATYFCARAYTSNSDIVFDPWGPGTLVTVSSGQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLTNGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTVAPSTCSGTKHHHHHH |
Light Chain: L
Mutation: NULL
| >7O9S_L|Chain B[auth L]|Fab nnHTN-Gn2 Light chain|Oryctolagus cuniculus (9986) TGQVLTQTPASVSAAVGGTVTIKCQASQSVSTALAWYQQKPGQRPKLLIYLASTLTSGVPSRFKGSGSGTEFTLTISGVECDDAATYYCQQGYSYSNVDNSFGGGTEVVVKGDPVAPSVLIFPPAADQVATGTVTIVCVANKYFPDVTVTWEVDGTTQTTGIENSKTPQNSADCTYNLSSTLTLTSTQYNSHKEYTCKVTQGTTSVVQSFNRGDC |
Antigen
Chain: A
Mutation: NULL
| >7O9S_A|Chain C[auth A]|Envelope polyprotein|Hantaan orthohantavirus (3052480) TGSLRNVYDMKIECPHTVSFGENSVIGYVELPPMPLADTAQMVPESSCSMDNHQSINTITKYTQVIWRGKADPGQSSQNSFETVSTEVDLKGTCVLKHKMVEESYRSRKSITCYDLSCNSTFCKPTLYMIVPIHACNMMKSCLIALGPYRVQVVYERTYCMTGVLIEGKCFVPDQSVVSIIKHGIFDIASVHVVCFFVAVKGNTYKLFEQVKKSFESTCNDTENKVQGYYICIVGGNSAPIYVPTLDDFRSMEAFTGIFKSPHGEDHDLAGEEIASYSIVGPANAKVPHSASSDTLSLIAYSGIPSYSSLSILTSSTDAKHVFSPGLFPKLNHTNCDKSAIPLTWTGMIDLPGYYEGTKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASN32 TYR51 THR52 GLY53 VAL55 ALA56 TRP57 LYS63 TYR96 THR97 SER98 ASN99 SER100 ASP101 ILE102 VAL103 L: GLN26 SER27 SER29 THR30 TYR48 LEU49 GLY90 TYR91 SER92 TYR93 SER94 ASN95 A: SER18 LEU19 ARG20 ASN21 VAL22 MET49 PRO50 ASP53 ALA55 GLN56 GLU60 SER61 SER62 MET65 SER156 CYS157 LEU158 ALA160 GLY162 PRO163 ARG165 GLN167 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
