Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4497 |
| PDBID: | 7NXX |
| Chains: | B_A |
| Organism: | Homo sapiens, Camelus dromedarius |
| Method: | XRD |
| Resolution (Å): | 2.19 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 7NXX VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human superoxide Dismutase 1 (SOD1) |
| Antigen mutation: | No |
| Durg Target: | P00441 |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >7NXX_B|Chain B|nanobody 2|Camelus dromedarius (9838) MAQVQLQESGGGSVQAGGSLRLACVASGGDTRPYITYWMGWYRQAPGKEREGVATIYTGGSGTYYSDSVEGRFTISQDKAQRTVYLQMNDLKPEDTAMYYCAAGNGALPPGRRLSPQNMDTWGPGTQVTVSSHHHH |
Antigen
Chain: A
Mutation: NULL
| >7NXX_A|Chain A|Superoxide dismutase [Cu-Zn]|Homo sapiens (9606) ATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition B: ARG32 PRO33 TYR34 ILE35 THR36 TRP38 TYR57 GLY59 GLY60 SER61 GLY62 TYR64 ASN105 GLY106 ALA107 ARG113 A: ASP11 GLY12 PRO13 VAL14 GLN15 LYS36 GLY37 LEU38 THR39 GLU40 LYS91 ASP92 GLY93 VAL94 GLU121 SER142 LEU144 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
