Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 447 |
| PDBID: | 3CSY |
| Chains: | EF_L |
| Organism: | Homo sapiens, Ebola virus - Mayinga, Zaire, 1976 |
| Method: | XRD |
| Resolution (Å): | 3.40 |
| Reference: | 10.1038/nature07082 |
| Antibody | |
| Antibody: | KZ52 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Ebola virus glycoprotein GP2 |
| Antigen mutation: | No |
| Durg Target: | Q05320 |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >3CSY_E|Chain A, C, E, G|Fab KZ52 heavy chain|Homo sapiens (9606) EVQLLESGGGLVKPGGSLRLSCAASGFTLINYRMNWVRQAPGKGLEWVSSISSSSSYIHYADSVKGRFTISRDNAENSLYLQMNSLRAEDTAVYYCVREGPRATGYSMADVFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Light Chain: F
Mutation: NULL
| >3CSY_F|Chain B, D, F, H|Fab KZ52 light chain|Homo sapiens (9606) ELVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKSYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSAPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNR |
Antigen
Chain: L
Mutation: NULL
| >3CSY_L|Chain J, L, N, P|Envelope glycoprotein GP2|Ebola virus - Mayinga, Zaire, 1976 (128952) EAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYTEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKIDQIIHDFVD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: THR28 ILE30 ASN31 TYR32 SER52 SER53 TYR56 PRO97 ARG98 ALA99 F: ASN28 LYS30 TYR32 TYR49 TRP50 THR53 GLU55 SER56 L: ALA503 ILE504 VAL505 ASN506 ALA507 GLN508 PRO509 LYS510 CYS511 PRO513 ASN514 HIS549 ASN550 GLN551 ASP552 GLY553 LEU554 CYS556 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
