Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4402 |
| PDBID: | 7N3C |
| Chains: | HL_C |
| Organism: | Homo sapiens, Severe acute respiratory syndrome coronavirus 2 |
| Method: | XRD |
| Resolution (Å): | 1.82 |
| Reference: | 10.1016/j.isci.2024.108976 |
| Antibody | |
| Antibody: | S24-202 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 Spike glycoprotein NTD |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7N3C_H|Chain A[auth H]|S24-202 Fab heavy chain|Homo sapiens (9606) EVQLVQSGAEVKKPGESLRISCKGSGYSFSSYWISWVRQMPGKGLEWMGRIDPSDSNTNYSPSFQGHVTISADKSISTAYLQWSSLKASDTAMYYCARLSVRVWFGELPHYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Light Chain: L
Mutation: NULL
| >7N3C_L|Chain B[auth L]|S24-202 Fab light chain|Homo sapiens (9606) AEIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRASGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRRNWPLTFGGGTKVETKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE |
Antigen
Chain: C
Mutation: NULL
| >7N3C_C|Chain C|Nucleoprotein|Severe acute respiratory syndrome coronavirus 2 (2697049) ANMNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: TRP33 VAL101 ARG102 VAL103 TRP104 PHE105 GLY106 LEU108 TYR111 L: SER30 SER31 TYR32 ASP50 ARG91 ARG92 ASN93 C: ARG68 GLY69 ASP81 ILE84 LEU113 GLY114 ALA119 GLY120 LEU121 PRO122 TYR123 ALA134 THR135 GLU136 GLY137 ALA138 LEU139 ASN140 THR141 PRO142 ASP144 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
