Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 44 |
| PDBID: | 1G6V |
| Chains: | K_A |
| Organism: | Bos taurus, Camelus dromedarius |
| Method: | XRD |
| Resolution (Å): | 3.50 |
| Reference: | 10.1074/jbc.M102107200 |
| Antibody | |
| Antibody: | CAB-CA05 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | bovine carbonic anhydrase |
| Antigen mutation: | No |
| Durg Target: | P00918 |
Sequence information
Antibody
Chain: K
Mutation: NULL
| >1G6V_K|Chain B[auth K]|ANTIBODY HEAVY CHAIN|Camelus dromedarius (9838) QVQLVESGGGSVQAGGSLRLSCAASGYTVSTYCMGWFRQAPGKEREGVATILGGSTYYGDSVKGRFTISQDNAKNTVYLQMNSLKPEDTAIYYCAGSTVASTGWCSRLRPYDYHYRGQGTQVTVSS |
Antigen
Chain: A
Mutation: NULL
| >1G6V_A|Chain A|CARBONIC ANHYDRASE|Bos taurus (9913) MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| K: THR831 TYR832 LEU852 THR898 VAL899 ALA900 SER901 THR902 GLY903 TRP904 ARG907 ARG909 ASP912 HIS914 TYR915 A: PRO46 LEU47 SER48 VAL49 SER50 TYR51 ASP52 LYS80 LYS154 ASP180 ARG182 GLY183 LEU185 PRO186 GLU187 SER188 LEU189 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
