Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 434 |
| PDBID: | 3BN9 |
| Chains: | FE_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.17 |
| Reference: | 10.1016/j.jmb.2008.05.009 |
| Antibody | |
| Antibody: | E2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Membrane-type serine protease 1 |
| Antigen mutation: | No |
| Durg Target: | Q9Y5Y6 |
Sequence information
Antibody
Heavy Chain: F
Mutation: NULL
| >3BN9_F|Chain C[auth D], F|E2 Fab Heavy Chain|Homo sapiens (9606) QVQLVQSGGGLVKPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMSSLRAEDTAVYYCARPYLTYPQRRGPQNVSPFDNWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCAAAHHHHHHGAAEQKLISEEDLNGAA |
Light Chain: E
Mutation: NULL
| >3BN9_E|Chain B[auth C], E|E2 Fab Light Chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQGISSYLAWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFAVYYCQQHGNLPYTFGDGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >3BN9_A|Chain A, D[auth B]|Membrane-type serine protease 1|Homo sapiens (9606) VVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPISLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTGV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: SER30 TYR32 GLY92 ASN93 LEU94 TYR96 F: PHE27 THR28 PHE29 SER30 SER31 ALA33 ALA50 ILE51 GLY52 SER53 GLY55 SER56 TYR58 ASN73 ASN76 THR98 TYR99 A: ILE41 CYS42 HIS57 CYS58 PHE94 ASN95 ASP96 PHE97 THR98 PHE99 HIS143 TYR146 GLY147 LEU172 PRO173 GLN174 GLN175 SER190 CYS191 GLN192 SER195 VAL213 SER214 TRP215 GLY216 ASP217 GLY219 CYS220 GLN221 LYS224 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
