Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4333 |
| PDBID: | 7MRZ |
| Chains: | XY_C |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1016/j.isci.2021.103590 |
| Antibody | |
| Antibody: | Anti-ActRIIB Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Activin receptor type-2B, Activin receptor type-1B |
| Antigen mutation: | No |
| Durg Target: | P36896 |
Sequence information
Antibody
Heavy Chain: X
Mutation: NULL
| >7MRZ_X|Chain C[auth X]|Fab Heavy Chain|Homo sapiens (9606) QLQLQESGPGLVKPSETLSLTCTVSGGSISSSSYYWGWIRQPPGKGLEWIGSISYSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDSLRYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: Y
Mutation: NULL
| >7MRZ_Y|Chain D[auth Y]|Fab Light Chain|Homo sapiens (9606) DIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYALAPPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >7MRZ_C|Chain B[auth C]|Activin receptor type-2B,Activin receptor type-1B|Homo sapiens (9606) SGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTGGGTHTCPPCPAPELLGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVATCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVETGGGTHTCPPCPAPELLG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition X: SER28 SER30 SER31 SER32 SER33 TYR34 TYR35 TYR55 SER56 THR75 SER76 ASN78 ARG99 ASP100 SER101 LEU102 ARG103 TYR104 Y: TYR253 SER255 ASN256 LYS258 TYR260 TRP278 LEU321 C: THR26 GLU28 ILE30 TYR32 GLN43 SER44 GLY45 LEU46 ARG48 GLY68 THR69 ILE70 LEU72 LYS75 GLN88 GLU89 ASN107 PHE108 CYS109 GLU111 ARG112 PHE113 THR114 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
