Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4326 |
| PDBID: | 7MMN |
| Chains: | MG_K |
| Organism: | Homo sapiens, Human respiratory syncytial virus A2, Tequatrovirus T4 |
| Method: | XRD |
| Resolution (Å): | 3.57 |
| Reference: | 10.1080/19420862.2021.1955812 |
| Antibody | |
| Antibody: | AM14 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Respiratory syncytial virus (RSV) Fusion glycoprotein F1 |
| Antigen mutation: | No |
| Durg Target: | P03420; P11209; P13843; |
Sequence information
Antibody
Heavy Chain: M
Mutation: NULL
| >7MMN_M|Chain J[auth D], K[auth H], L[auth M]|AM14 Fab Heavy Chain|Homo sapiens (9606) CVQLVESGGGVVQPGRSLRLSCAASGFSFSHYAMHWVRQAPGKGLEWVAVISYDGENTYYADSVKGRFSISRDNSKNTVSLQMNSLRPEDTALYYCARDRIVDDYYYYGMDVWGQGATVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKGSENLYFQGSHHHHHH |
Light Chain: G
Mutation: NULL
| >7MMN_G|Chain A[auth E], B[auth G], C[auth L]|AM14 Fab Light Chain|Homo sapiens (9606) GDIQMTQSPSSLSASVGDRVTITCQASQDIKKYLNWYHQKPGKVPELLMHDASNLETGVPSRFSGRGSGTDFTLTISSLQPEDIGTYYCQQYDNLPPLTFGGGTKVEIKRTVRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: K
Mutation: NULL
| >7MMN_K|Chain E[auth B], G[auth I], I[auth K]|Fusion glycoprotein F1,Fibritin|Human respiratory syncytial virus (11259) FLGFLLGVGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGGLVPR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition G: TYR33 ASP51 TYR92 ASP93 ASN94 M: HIS31 TYR53 ASP54 GLU56 ARG100 ILE101 ASP103 ASP104 TYR105 TYR106 TYR107 TYR108 K: ASN426 LYS427 ASN428 ARG429 ILE432 LYS445 GLY446 LYS461 GLU463 LYS465 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
