Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 431 |
| PDBID: | 3BGF |
| Chains: | HL_S |
| Organism: | Severe acute respiratory syndrome-related coronavirus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1016/j.jmb.2009.03.042 |
| Antibody | |
| Antibody: | F26G19 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS coronavirus spike receptor binding domain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3BGF_H|Chain D[auth B], F[auth H]|F26G19 Fab|Mus musculus (10090) EVQLEESGTVLARPGASVKMSCKASGYTFTTYRMHWIKQRPGQGLEWIGAIYPGNSDTTYNQKFKDKAKLTAVTSTSSAYMELSSLTNEDSAVYFCTREGIPQLLRTLDYWGQGTSVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEP |
Light Chain: L
Mutation: NULL
| >3BGF_L|Chain C, E[auth L]|F26G19 Fab|Mus musculus (10090) DILMTQSPSSLSASLGERVSLTCRASQEISGYLSWLQEKPDGTIKRLIYAASTLDSGVPKRFSGSRSGSDYSLTISSLESEDFADYYCLQYVSYPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: S
Mutation: NULL
| >3BGF_S|Chain A, B[auth S]|Spike protein S1|SARS coronavirus (694009) NITNLCPFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTPPALNCYWPLNDYGFYTTTGIGYQPYRVVVLSFELLNAPATV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: SER30 TYR32 VAL92 SER93 TYR94 PRO95 H: THR30 THR31 ARG33 GLY53 ASN54 ASP56 THR57 THR58 THR73 GLU95 GLY96 ILE97 PRO98 GLN99 S: THR359 PHE360 PHE361 SER362 GLY391 ASP392 VAL394 ARG395 ASN424 ARG426 ASN427 THR485 THR486 THR487 GLY488 ILE489 GLY490 TYR491 GLN492 TYR494 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
