Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4258 |
| PDBID: | 7M3N |
| Chains: | HL_A |
| Organism: | Mus musculus, Canine parvovirus |
| Method: | EM |
| Resolution (Å): | 2.40 |
| Reference: | 10.1073/pnas.2025452118 |
| Antibody | |
| Antibody: | 14 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Canine parvovirus Capsid protein 2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7M3N_H|Chain B[auth H]|CPV Fab14 heavy chain|Mus musculus (10090) AVHLQGTELVKPGASAGVKLSCKASGYTFTNYDMNWVRQRPEQGLEWIGWIFPGDGSTRYNEKFKGKATLTTDKSSSTAYQLNRLTSEDSAVYFCARRGSHGSYSFAYWGQGTLVTVSG |
Light Chain: L
Mutation: NULL
| >7M3N_L|Chain A[auth L]|CPV Fab14 light chain|Mus musculus (10090) DIVMTQSHKFMSTSVGDRVSITCKASQDVNTALAWYQQIPGQSPKLLIYSASNRYTGVPDRFTASGSGTDFTFTISSVQAEDLALYYCQQHYTTPWTFGGGTKLEIKR |
Antigen
Chain: A
Mutation: NULL
| >7M3N_A|Chain C[auth A]|Capsid protein 2|Canine parvovirus type 2 (10788) MSDGAVQPDGGQPAVRNERATGSGNGSGGGGGGGSGGVGISTGTFNNQTEFKFLENGWVEITANSSRLVHLNMPESENYRRVVVNNMDKTAVNGNMALDDIHAQIVTPWSLVDANAWGVWFNPGDWQLIVNTMSELHLVSFEQEIFNVVLKTVSESATQPPTKVYNNDLTASLMVALDSNNTMPFTPAAMRSETLGFYPWKPTIPTPWRYYFQWDRTLIPSHTGTSGTPTNIYHGTDPDDVQFYTIENSVPVHLLRTGDEFATGTFFFDCKPCRLTHTWQTNRALGLPPFLNSLPQSEGATNFGDIGVQQDKRRGVTQMGNTNYITEATIMRPAEVGYSAPYYSFEASTQGPFKTPIAAGRGGAQTDENQAADGNPRYAFGRQHGQKTTTTGETPERFTYIAHQDTGRYPEGDWIQNINFNLPVTNDNVLLPTDPIGGKTGINYTNIFNTYGPLTALNNVPPVYPNGQIWDKEFDTDLKPRLHVNAPFVCQNNCPGQLFVKVAPNLTNEYDPDASANMSRIVTYSDFWWKGKLVFKAKLRASHTWNPIQQMSINVDNQFNYVPSNIGGMKIVYEKSQLAPRKLY |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition L: ASN30 THR31 ALA32 TYR49 SER50 ASN53 HIS91 TYR92 TRP96 H: THR30 ASN31 TYR32 ASP33 PHE52 GLY54 ASP55 SER57 ARG98 SER100 HIS101 GLY102 SER103 TYR104 A: MET87 ASP88 LYS89 ALA91 VAL92 ASN93 ASN95 HIS222 THR223 GLY224 THR225 SER226 GLY227 THR228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
