Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4211 |
| PDBID: | 7LVW |
| Chains: | L_C |
| Organism: | Respiratory syncytial virus, Lama glama |
| Method: | XRD |
| Resolution (Å): | 2.10 |
| Reference: | 10.1128/JVI.02279-20 |
| Antibody | |
| Antibody: | Cl184 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | RSV fusion glycoprotein |
| Antigen mutation: | No |
| Durg Target: | P03420; P11209; |
Sequence information
Antibody
Chain: L
Mutation: NULL
| >7LVW_L|Chain B[auth G], H, I, J, K, L|F-VHH-Cl184|Lama glama (9844) MRPTWAWWLFLVLLLALWAPARGQVQLQESGGGLVQAGGSLRLSCAASGQTFSGYVTGWFRQAPGKEREFVALIAWSGGRLYYADSVQGRFTISRDNAETTVYLQMNSLKPEDTAVYYCAAKRGGAVTAAEWYDYWGQGTQVTVSSHHHHHH |
Antigen
Chain: C
Mutation: NULL
| >7LVW_C|Chain A, C[auth B], D[auth C], E[auth D], F[auth E], G[auth F]|Fusion glycoprotein F0|Respiratory syncytial virus (12814) QNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKEIKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGSLEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition L: GLN1 GLN27 SER30 GLY31 TYR32 VAL33 TRP52 SER53 ARG56 ASN73 GLU75 LYS95 ARG96 GLY97 GLY98 ALA99 ASP101 TYR102 C: ASN27 THR29 GLU30 GLU31 TYR33 VAL40 LYS42 GLY43 ASP310 THR311 PRO312 TRP314 ASP344 GLY347 SER377 GLU378 ASN380 LEU381 ASN383 VAL384 ASP385 ASN388 PRO389 LYS390 LYS465 SER466 LEU467 VAL469 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
