Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 4208 |
| PDBID: | 7LUE |
| Chains: | JN_C |
| Organism: | Respiratory syncytial virus A2, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 2.90 |
| Reference: | 10.1016/j.immuni.2021.03.004 |
| Antibody | |
| Antibody: | ADI-14442 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | respiratory syncytial virus (RSV) Fusion glycoprotein F0 |
| Antigen mutation: | No |
| Durg Target: | P03420; P11209; P13843; |
Sequence information
Antibody
Heavy Chain: J
Mutation: NULL
| >7LUE_J|Chain D[auth H], E[auth I], F[auth J]|Heavy chain of human antibody Fab ADI-14442|Homo sapiens (9606) QVQLVQSGSEVKKPGASVKVSCKASGYRFSNYGISWVRQAPGQGLEWMGWISAYNGNIKYGNNLQGRVTVTTDTSTATAYMEVRSLTSDDTAVYYCARDVPADGVHFMDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCD |
Light Chain: N
Mutation: NULL
| >7LUE_N|Chain G[auth L], H[auth M], I[auth N]|Light chain of human antibody Fab ADI-14442|Homo sapiens (9606) DVVMTQSPLSLPVTLGQPASISCRSSQSLVHSDTNTYLNWFQQRPGQSPRRLIYKVSNRDSGVPDRFSGSGSGTTFTLKISRVEAEDVGIYYCMQGSHWAPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >7LUE_C|Chain A, B, C|Fusion glycoprotein F0|Respiratory syncytial virus A2 (1972429) QNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKEIKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGSLEVLFQGPGHHHHHHHHSAWSHPQFEK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition J: ARG28 ASN31 TYR32 TYR53 ASN54 ASN56 VAL96 PRO97 ALA98 ASP99 N: SER27 ASP28 THR29 ASN30 THR31 TYR32 ARG46 TYR49 LYS50 SER52 ASN53 C: TYR53 LEU172 SER173 THR174 ASN175 LYS176 ALA177 VAL178 SER180 SER186 LEU188 LYS191 VAL192 LEU193 ASP194 ASN197 TYR198 LYS201 GLN202 LYS226 GLU256 SER259 ASN262 ASP263 MET264 PRO265 LYS271 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
